The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [<cite idref="PUB00004459"/>]. The gene is highly similar to the <taxon tax_id="7227">Drosophila melanogaster</taxon> segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [<cite idref="PUB00004459"/>]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction. <p> In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters. </p><p>The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role in the development of normal hematopoiesis. CBF is a nuclear protein expressed in numerous tissue types, except brain and heart; highest levels have been found to occur in thymus, bone marrow and peripheral blood.</p> Acute myeloid leukemia 1 protein (AML 1)/Runt